T-Cell Acute lymphoblastic leukaemia (T-ALL)

Description: 
Available tests
Karyotyping
Fluorescence in situ hybridisation: BCR-ABL to detect episomal amplification of ABL; MLL to detect 11q23 rearrangement
Clinical details: 
Cytogenetic analysis in T-cell acute lymphoblastic leukaemia (T-ALL) can aid in the diagnosis of disease and identify markers which can then be used to assess remission status and in disease monitoring. T-ALL FISH testing strategy:
Synonyms or keywords: 
T-ALL, T-cell ALL, T-cell acute lymphoblastic leukaemia, BCR-ABL, NUP214/ABL, MLL
Department: 
Genetics Department
Location: 
Guy's Hospital
Sample type and Volume required: 
Peripheral blood, bone marrow aspirate, pleural effusion, fine needle aspirate, as appropriate, minimum volume as available
Turnaround time: 
Current service turnaround times: Urgent 1-7 calendar days; Non-urgent 5-10 calendar days; National targets: Urgent samples 95% reported within 14 days; Non-urgent 95% reported within 21 days
Criteria for acceptance / rejections of sample
Storage and transport: 
Peripheral blood in lithium heparin or bone marrow transport medium. All other samples in bone marrow transport medium. Do not spindown or freeze samples beforesending. Samples must arrive within 24 hours
Contacts:
Oncology Cytogenetics Laboratory at Guy's Hospital
020 7188 1713
viapath.OncologyDutyScientist@nhs.net
Genetics Department
Tower Wing - 5th Floor
Guy's Hospital
Great Maze Pond
London SE1 9RT

For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Oncology Cytogenetics at Guy's

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Last updated: 24/01/2020