B-cell chronic lymphocytic leukaemia (B-CLL)

Description: 
Interphase fluorescence in situ hybridisation for: TP53(17p13.1) deletion; ATM (11q22.3) deletion;
DLEU(13q14)/LAMP(13q34) to detect del(13q); CEP12 to detect trisomy 12
Clinical details: 
Cytogenetic abnormalities detected by interphase FISH analysis are well-established prognostic markers in patients with a known diagnosis of B-cell chronic lymphocytic leukaemia (B-CLL).
Synonyms or keywords: 
CLL, chronic lymphocytic leukaemia, TP53, p53, ATM, 17p, del(11q) del(13q), trisomy 12
Department: 
Genetics Department
Location: 
Guy's Hospital
Sample type and Volume required: 
Peripheral blood, bone marrow aspirate, as appropriate, minimum volume as available
Turnaround time: 
Current service turnaround times: Urgent 1-7 calendar days; Non-urgent 5-10 calendar days; National targets: Urgent samples 95% reported within 14 days; Non-urgent 95% reported within 21 days
Criteria for acceptance / rejections of sample
Storage and transport: 
Peripheral blood in lithium heparin or bone marrow transport medium. All other samples in bone marrow transport medium. Do not spindown or freeze samples before sending. Samples must arrive within 24 hours
Contacts:
Oncology Cytogenetics Laboratory at Guy's Hospital
020 7188 1713
viapath.OncologyDutyScientist@nhs.net
Genetics Department
Tower Wing - 5th Floor
Guy's Hospital
Great Maze Pond
London SE1 9RT

For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Oncology Cytogenetics at Guy's

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Last updated: 07/08/2015