Thrombin time
Description:
Bovine thrombin is added directly to test plasma and time taken to clot recorded
Clinical details:
The thrombin time involves direct conversion of test fibrinogen to fibrin in vitro. Elevated thrombin time can be due to:
● hereditary or acquired deficiencies of fibrinogen concentration or function
● autoantibodies/inhibitors to fibrinogen or thrombin
● elevated D-dimers
● liver disease
● anticoagulant therapy with heparins, direct thrombin inhibitors
● some paraproteins.
● hereditary or acquired deficiencies of fibrinogen concentration or function
● autoantibodies/inhibitors to fibrinogen or thrombin
● elevated D-dimers
● liver disease
● anticoagulant therapy with heparins, direct thrombin inhibitors
● some paraproteins.
Reference range:
0.9 - 1.1
Units:
Ratio
Department:
Location:
Sample type and Volume required:
External requests: Citrated platelet poor plasma
400µL x 1 aliquot
Internal requests: please refer to EPR label
400µL x 1 aliquot
Internal requests: please refer to EPR label
Turnaround time:
4 hours
Special sample instructions:
The sample should be analysed within 4 hours of venepuncture. Please ensure sample tubes are filled exactly to the fill-line as underfilling creates a dilution error and leads to inaccurate results.
Contacts:
Diagnostic Haemostasis and Thrombosis Department
St Thomas': 020 7188 2797; Guy's: 020 7188 7188 ext. 53860
St Thomas' Hospital
North Wing - 4th and 5th Floors
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
24/7
Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Outside core hours, contact Duty Haemostasis Biomedical Scientist
North Wing - 4th and 5th Floors
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
24/7
Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Outside core hours, contact Duty Haemostasis Biomedical Scientist
Last updated: 03/10/2022
