HLA Antibody Screening
Description:
Luminex© based assays to determine the presence or absence of HLA antibodies (screen) and to determine the HLA specificity of the antibodies detected (single antigen beads HLA A, B, C, DRB1, DQB1, DQA1, DPB1, DPA1, DRB3/4/5)
Clinical details:
In solid organ transplantation the presence of HLA donor specific antibodies is associated with graft loss and graft dysfunction. Characterisation of HLA specific antibodies is used to:
· Identify immunological risk at time of transplant to guide clinical management
· Identify HLA donor specific antibodies post transplant to guide clinical management
· Monitor HLA donor specific antibodies in antibody incompatible kidney transplantation
· Optimise donor selection in HLA mismatched allogeneic bone marrow and stem cell transplantation
· Identify immunological risk at time of transplant to guide clinical management
· Identify HLA donor specific antibodies post transplant to guide clinical management
· Monitor HLA donor specific antibodies in antibody incompatible kidney transplantation
· Optimise donor selection in HLA mismatched allogeneic bone marrow and stem cell transplantation
Reference range:
none
Synonyms or keywords:
HLA antibodies
urgent
DSA
Units:
none
Department:
Location:
Sample type and Volume required:
5 ml Clotted blood
Call in advance:
for urgent (same day) testing, please call 020 7188 1540
Turnaround time:
2 weeks
Special sample instructions:
none
Storage and transport:
UN3373 packaging
Time limit for extra tests:
none
Contacts:
Clinical Transplantation Department at Guy's Hospital
Laboratory Enquiry: 020 7188 1540
Clinical Transplantation Department
Guy's Hospital
Borough Wing - 3rd Floor
Great Maze Pond
London SE1 9RT
Guy's Hospital
Borough Wing - 3rd Floor
Great Maze Pond
London SE1 9RT
Last updated: 07/08/2015
