Factor inhibitor (factors other than FVIII & FIX)

Description: 
Dilutions of test plasma (i.e. reducing concentrations of inhibitor) are incubated for a short period (30 minutes) at 37°C in the presence of a fixed amount of exogenous coagulation factor in the Bethesda assay. One unit of inhibitor is defined as the amount of inhibitor that will neutralise 50% of a normal plasma containing 100% coagulation factor. The amount of residual factor in each tube is used to calculate the inhibitor level.
Clinical details: 
Acquired inhibitors to any of factors II, V, VII, X & XI as a result of recognising therapeutic products as 'foreign' protein, or in patients with previously normal haemostasis as part of an autoimmune process, are extremely rare. Inhibitors in congenital deficiencies complicate treatment as the infused factor has a shorter survival time, and patients with acquired coagulation factor deficiency can present with severe bleeding.
Related condition or disease: 
Rare coagulation factor deficiencies & inhibitors
Reference range: 

Not detected

Units: 
BU/ml
Department: 
Haemostasis and Thrombosis Department
Location: 
St Thomas' Hospital
Sample type and Volume required: 
External requests: Citrated platelet poor plasma
1mL x 1 aliquot
Internal requests: please refer to EPR label

Turnaround time: 
10 - 14 days
Special sample instructions: 

The sample should be analysed or manipulated & stored in the laboratory within 4 hours of venepuncture. Please ensure sample tubes are filled exactly to the fill-line as underfilling creates a dilution error and leads to inaccurate results.

Criteria for acceptance / rejections of sample
Contacts:
Diagnostic Haemostasis and Thrombosis Department
St Thomas': 020 7188 2797; Guy's: 020 7188 7188 ext. 53860
St Thomas' Hospital
North Wing - 4th and 5th Floors
Westminster Bridge Road
London SE1 7EH

Laboratory opening times
24/7

Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT

Outside core hours, contact Duty Haemostasis Biomedical Scientist
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Diagnostic Haemostasis and Thrombosis Laboratory at Guy's and St Thomas'

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Last updated: 08/03/2017