Apolipoprotein A1
Description:
Apolipoprotein A-1 is the major protein constituent of high density lipoproteins (HDL) which is involved in reverse cholesterol transport.
Apo A-1 is often used as a biomarker for prediction of cardiovascular diseases and the ratio Apo B-100/ApoA-1 is a better predictor of the risk.
Apo A-1 is often used as a biomarker for prediction of cardiovascular diseases and the ratio Apo B-100/ApoA-1 is a better predictor of the risk.
Clinical details:
Apo A-1 comprises 65% of the apolipoprotein of HDL (high density lipoprotein), providing structural scaffold for its formation. It is also a co-factor for lecithin cholesterol acyl transferase (LCHAT), required for esterification of cholesterol to cholesteryl esters.
HDL is involved in the reverse transport of cholesterol from peripheral tissues to the liver, from where it can be excreted. Hence Apo A-1 deficiency confers increased risk of coronary artery and peripheral vascular disease, even in the absence of other coronary risk factors.
HDL is involved in the reverse transport of cholesterol from peripheral tissues to the liver, from where it can be excreted. Hence Apo A-1 deficiency confers increased risk of coronary artery and peripheral vascular disease, even in the absence of other coronary risk factors.
Reference range:
See Chemistry Reference Ranges Document at Automated Chemistry Laboratory at Guy's and St Thomas'
Synonyms or keywords:
Apo A,
Apolipoprotein A
Units:
g/L
Department:
Last updated: 08/11/2021
