Apo E Genotype
Description:
Analysis of Apo E gene for three common alleles (e2, e3, e4) encoding 3 protein isoforms (E2, E3, E4) differing at amino acid positions 112 and 158.
Clinical details:
The E2 isoform binds the lipoprotein receptors with only 2 percent of the affinity of E3 and E4 resulting in impaired clearance of chylomicron and VLDL remnants and increased plasma cholesterol and triglyceride levels.
Allele frequencies
e2 – 10% e3 – 75% e4 – 15%
Homozygosity e2 – 1% of Caucasians
ApoE e3 is the wild-type allele.
ApoE e2/e2 – strong association with HLP III
Allele frequencies
e2 – 10% e3 – 75% e4 – 15%
Homozygosity e2 – 1% of Caucasians
ApoE e3 is the wild-type allele.
ApoE e2/e2 – strong association with HLP III
Reference range:
n/a
Synonyms or keywords:
Apo E genotype
Apolipoprotein E
Type III hyperlipoproteinemia.
Units:
n/a
Department:
Location:
Last updated: 14/03/2017
