Ovarian antibodies

Description: 
Autoantibodies to ovarian tissue are mainly restricted to the theca cells. These are steroid producing cells and it has been demonstrated that the molecular target is the enzyme 17/alpha-hydroxylase (17/alpha-OH). Antibodies to 17/alpha-OH are found in patients with ovarian failure with autoimmune Addison’s disease (100%) and to a lesser extent in both autoimmune polyendocrine syndromes types 1 and 2 without ovarian failure. The incidence is reportedly very low in other autoimmune disorders such type1 diabetes and thyroid disease. The assay is an indirect immunofluorescence type using monkey ovary as a substrate.
Reference range: 

Negative

Units: 
Negative / Positive
Department: 
Diagnostic Immunology and Allergy Department
Location: 
King's College Hospital
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
21 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Criteria for acceptance / rejections of sample
Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Diagnostic Immunology Laboratory at King's

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Last updated: 23/05/2023