dsDNA antibodies (Crithidia)

Description: 
dsDNA Crithidia luciliae is an indirect immunofluorescent assay for the screening and semi-quantitative determination of anti-double stranded DNA (dsDNA) in human serum. The presence of anti-double stranded DNA can be used in conjunction with other serological tests and clinical findings to aid in the diagnosis of systemic lupus erythematosus (SLE). In general, anti-native dsDNA antibodies are not found in other rheumatic diseases, but if present, their titre is usually lower than those in SLE patients. They may be seen in autoimmune chronic active hepatitis and in rheumatoid arthritis treated with sulphasalazine.
Related condition or disease: 
Systemic lupus erythematosus (SLE)
Reference range: 

Negative

Synonyms or keywords: 
DNA, Crithidia
Units: 
Negative/ Equivocal/ Positive
Department: 
Diagnostic Immunology and Allergy Department
Location: 
King's College Hospital
Sample type and Volume required: 
Serum
Turnaround time: 
6 days
Criteria for acceptance / rejections of sample
Storage and transport: 
Samples may be stored at 4°C prior to dispatch. The use of first class letter post without the need for coolant is sufficient
Time limit for extra tests: 
10 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Diagnostic Immunology Laboratory at King's

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Last updated: 03/11/2021