Chemokine CXCL10
Description:
CXCL10 is a pro-inflammatory cytokine secreted in response to IFN-γ by a variety of cells. Binding of CXCL10 to its receptor, CXCR3, promotes the migration of T cells and monocytes, regulating the immune response. CXCL10 is a biomarker of T cell activity.
Clinical details:
In many inflammatory diseases, immune system dysfunction causes CXCL10 to be raised resulting in inflammation. CXCL10 has been shown to be raised in inflammatory disease, such as type 1 diabetes, rheumatoid arthritis, cryoglobulinaemia, SLE, Sjögren’s syndrome, and Behçet’s Disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of coronavirus which causes the coronavirus disease known as COVID-19 7. Severe fever and pneumonia leading to “cytokine storm” causes acute respiratory distress syndrome (ARDS) in approximately 20% of patients and is associated with severe disease. Circulating CXCL10 has been shown to be raised in COVID-19, suggesting T cell activation. Raised CXCL10 is associated with disease severity and has been suggested as a biomarker of COVID-19 severity and outcome.
Reference range:
38 - 361
Synonyms or keywords:
IP10, Covid-19
Units:
pg/mL
Department:
Sample type and Volume required:
SST (yellow top)
Turnaround time:
7 days
Special sample instructions:
Allow samples to clot for 30 minutes after being taken. Samples must then be centrifuged and frozen immediately. External requestors must send frozen samples on dry ice.
Storage and transport:
Samples stored at -30°C
Time limit for extra tests:
A separate sample is required for extra tests
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Laboratory:
Last updated: 03/07/2022
