Tramadol and metabolites
Description:
Tramadol, N-desmethyltramadol and O-desmethyltramadol by LC-HR-MS
Clinical details:
Tramadol is an opioid analgesic with significant abuse potential. It is metabolised to O- and N-desmethyltramadol, both of which are measured separately and are reported together with the parent drug to give a ‘total tramadol’ concentration in urine samples.
Reference range:
(cut-off) 200 µg/L
Department:
Location:
Sample type and Volume required:
Random urine sample (10–20 mL) collected into a plain 30 mL universal container. Please ensure containers are tightly sealed, and are sent in a clear plastic bag separate from the accompanying request form. Please also ensure containers are labelled with the full name and date of birth of the client, and the specimen collection date and time.
Turnaround time:
3-5 working days
Special sample instructions:
Additional specialist tests by enzymatic assay (urine ethanol), immunoassay (barbiturates), and by LC-HR-MS (buprenorphine and metabolites, ketamine and norketamine, and mephedrone - see other analytes in the ‘Our Tests’ section of the website) are available on request, and can be carried out on the same specimen as supplied originally.
Storage and transport:
Please refrigerate (if possible) if not sending immediately. Send by first class post.
Contacts:
Toxicology Department at King's Hospital
020 3299 5881
kch-tr.toxicology@nhs.net
King's College Hospital
Bessemer Wing - 3rd Floor
Denmark Hill
London SE5 9RS
Bessemer Wing - 3rd Floor
Denmark Hill
London SE5 9RS
Laboratory:
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*SLaM - South London and Maudsley NHS Foundation Trust
Last updated: 03/10/2022
