Fibrinogen antigen
Description:
Immuno-turbidimetric assay using latex particles coated with polyclonal rabbit anti-human fibrinogen antibodies, for the in vitro determination of fibrinogen. When the tested sample is mixed with the latex reagent (R1), the anti-fibrinogen antibodies coupled onto latex particles react with fibrinogen present in the sample and agglutination occurs. The amount of agglutination is directly proportional to the amount of fibrinogen in the sample and is measured by light absorption (at a wavelength of 405nm).
This test is not currently included in the laboratory's UKAS scope of accreditation to ISO15189:2012.
This test is not currently included in the laboratory's UKAS scope of accreditation to ISO15189:2012.
Clinical details:
The final stage in the molecular co-operation of the procoagulant participants of secondary haemostasis is the conversion of soluble fibrinogen monomers to insoluble, cross-linked fibrin polymers to stabilse the blood clot. Fibrinogen is a large, symmetrical dimeric glycoprotein composed of two identical sub-units, each of which is comprised of three non-identical polypeptide chains. It is present in plasma at a high concentration and is also contained in platelet α-granules. Fibrin is formed by thrombin cleavage of the small fibrinopeptides A & B from intact fibrinogen molecules that exposes donor sites that interlock with complementary unshielded acceptor sites on adjacent molecules to promote polymerisation.Quantitative and qualitative deficiencies of fibrinogen can be congenital or acquired and give rise to bleeding. More rarely, some dysfibrinogenemias can predispose to thrombosis.
Reference range:
1.74-3.48g/L
Units:
g/l
Department:
Location:
Last updated: 09/07/2021
