HLA Typing for Drug Hypersensitivity

Description: 
Possession of some specific HLA alleles are associated with adverse reactions when a patient is treated with a number of drugs. A variety of methods and technologies are used, including Next Generation Sequencing (NGS), PCR-SSP and PCR-SSOP (Luminex) to determine HLA Class I (HLA-A, B, C) and/or HLA Class II (DRB1/3/4/5, DQB, DQA, DPB, DPA) alleles. The method of testing and the locus of HLA tested will depend on the potential drug reaction under investigation and the clinical details provided.
Clinical details: 
The associations between HLA genes and adverse reaction to treatment with a variety of drugs are well established. Knowledge of a patients HLA type can assist in confirming a hypersensitivity reaction, or may be used to screen a patient prior to commencing treatment The list provided below is not exhaustive – please contact the laboratory to discuss any additional association queries. NB Please see HLA B*57:01 status listing for Abacavir Hypersensitivity.
Related condition or disease: 
Allopurinol Hypersensitivity – HLA-B*58:01;
Carbamazepine Hypersensitivity – HLA-A*31:01, B*15:02
Reference range: 

none

Synonyms or keywords: 
HLA typing, Drug Hypersensitivity
Units: 
none
Department: 
Clinical Transplantation Department
Location: 
Guy's Hospital
Sample type and Volume required: 
10ml EDTA blood
Call in advance: 
No
Turnaround time: 
10 working days
Special sample instructions: 

none

Criteria for acceptance / rejections of sample
Storage and transport: 
UN3373 packaging, room temperature
Time limit for extra tests: 
none
Contacts:
Clinical Transplantation Department at Guy's Hospital
Laboratory Enquiry: 020 7188 1540
Clinical Transplantation Department
Guy's Hospital
Borough Wing - 3rd Floor
Great Maze Pond
London SE1 9RT
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Clinical Transplantation Laboratory at Guy's Hospital

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Last updated: 11/08/2023