GBM (Glomerular Basement Membrane) Antibodies

Description: 
Autoantibodies to glomerular basement membrane (GBM) are found in Goodpasture’s syndrome. The target antigen is the NC1 domain of the alpha-3 chain of type IV collagen. This molecule forms the basis of the ELISA used in the detection of anti-GBM. Anti-GBM antibodies may occur in association with anti-neutrophil cytoplasmic antibodies (ANCA) and we therefore recommend parallel testing.
Related condition or disease: 
Goodpastures syndrome
Reference range: 

<7

Units: 
U/ml
Department: 
Diagnostic Immunology and Allergy Department
Location: 
King's College Hospital
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Call in advance: 
If urgent
Turnaround time: 
2 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Criteria for acceptance / rejections of sample
Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Diagnostic Immunology Laboratory at King's

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Last updated: 03/11/2021