Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children.

Thursday, 1 September, 2016
  • Adamusiak AM,
  • Stojanovic,
  • Dr Olivia Shaw ,
  • Sebire NJ,
  • Drage M,
  • Kessaris N,
  • Marks SD,
  • Mamode N

Abstract

BACKGROUND:

Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors.

METHODS:

We adopted our well-established adult desensitization protocol for this purpose and undertook HLA antibody-incompatible living donor renal transplants in two children: a 14-year-old girl and a 13-year-old boy.

RESULTS:

After 2 and 1.5 years of follow-up, respectively, both patients have stable renal allograft function despite a rise in donor-specific antibodies in one case.

CONCLUSIONS:

HLA-incompatible transplantation should be considered in selected cases for sensitized children.

Where Can I Read This Full Article?

The full article is available to read here

2016 Sep 1. [Epub ahead of print]

PMID: 27585679